Albumin infusion ameliorates liver injury in streptozotocin-induced diabetic rats

We investigated the effect of an albumin infusion on enzyme activity, expression level cytochrome P450 2E1 (CYP2E1), and oxidative stress in serum liver streptozotocin (STZ)-induced diabetic rats. The STZ treatment enhanced alanine aminotransferase aspartate activities rat compared with those untreated Treatment elevated catalytic activity CYP2E1, stress, decreased reducing potentials liver, suggesting possibility diabetes-induced injury. Moreover, antioxidant In contrast, administration purified from intact rats to restored these deleterious indices concentration-dependent manner. These results suggest that exogenous alleviates damage induced by type 1 diabetes.